Disease: gastric cancer (PMID:25763542)
Dysfunction type: interaction
Description: The expression of lncRNA AK022798 was significantly higher in all pcDNA3-Notch 1 plasmid treatment groups than in the pcDNA3 plasmid treatment group (P< 0.01).Overexpression of lncRNA AK022798 promotes SGC7901/DDP and BGC823/DDP cells apoptosis.the expression of MRP1 and P-glycoprotein decreased significantly in SGC7901/DDP and BGC823/DDP cells, and their apoptosis as well as the expressions of caspase 3 and caspase 8.
Function Mechanism: NA (PMID:25763542)
Biological Process: pathogenic process