ASBEL promotes proliferation and tumorigenicity of tumor cells.
BTG3-AS1:BTG3 antisense RNA 1
ASBEL is transcribed from chromosome 21 (21q21.1), and encodes a conserved, 2-kb ncRNA (termed ASBEL [antisense ncRNA in the ANA/BTG3 (three) locus]). The 5' region of ASBEL is complementary to a portion of the 5' untranslated region (UTR) and the first exon of ANA/BTG3 mRNA .
ASBEL expression is higher in stage I–III colon cancer than in normal tissues .
β-catenin is found to directly enhance the transcription of ASBEL .
ASBEL represses transcripting of ATF3, and ATF3 functions as a component in the negative feedback loop that inhibits ASBEL expression .
In ovarian carcinoma, ASBEL promotes tumorigenesis through suppressing translation of the sense gene (ANA/BTG3) . ASBEL forms duplexes with ANA/BTG3 mRNA in the nucleus and suppresses its cytoplasmic transportation, leading to negative regulation of ANA/BTG3 at protein level without changing of its mRNA level .
ASBEL also plays a key role in Wnt/β-catenin-mediated tumorigenesis . ASBEL interacts with and recruits transcription factor 3 (TCF3) to the activating transcription factor 3 (ATF3) locus and represses the expression of ATF3, resulting in proliferation and tumorigenicity of colon tumor cells .
- ovarian cancer 
- colorectal cancer 
Labs working on this lncRNA
- Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
- Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.
- Yanagida S, Taniue K, Sugimasa H, Nasu E, Takeda Y, Kobayashi M, Yamamoto T, Okamoto A, Akiyama T. ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma. Sci Rep. 2013;3:1305.
- Taniue K, Kurimoto A, Takeda Y, Nagashima T, Okada-Hatakeyama M, Katou Y, Shirahige K, Akiyama T. ASBEL-TCF3 complex is required for the tumorigenicity of colorectal cancer cells. Proc Natl Acad Sci U S A. 2016 Oct 21.