BOK-AS1 (BOK antisense RNA 1)
The BOK-AS1 gene consists of 2 exons and it is a natural antisense transcript of the hBok gene. The full-length BOK-AS1 transcript has 855 nucleotides but does not contain a long open reading frame, giving 79 amino acids in conceptually translation.
BOK-AS1 function specifically in the human testis, where it serves as an antisense molecule to regulate Bok-induced apoptosis. Overexpression of BOK-AS1 reduced Bok-induced cell death. To assess the effect of BOK-AS1 on Bok-induced apoptosis, overexpressed ectopically BOK-AS1 in HeLa cells showed expression of BOK-AS1 alone exhibited no significant anti- or pro-apoptotic activity when compared with control plasmids.
|Experiment||Forward primer||Reverse primer|
>gi|289629233|ref|NR_033346.1| Homo sapiens BOK antisense RNA 1 (BOK-AS1), antisense RNA
Labs working on this lncRNA
- University Women's Hospital Basel and Research Department of University Hospital, CH-4031 Basel, Switzerland.
- Zhang H, Gao S, De Geyter C. A natural antisense transcript, BOKAS, regulates the pro-apoptotic activity of human Bok. Int J Oncol. 2009 Apr;34(4):1135-8.