BMNCR

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BMNCR, a lncRNA that involves in the regulation of osteogenic and adipogenic.

Annotated Information

Name

Approved symbol: BMNCR

Approved name: BMNCR: bone marrow associated non-coding RNA

HGNC ID: HGNC: 54188

Entrez Gene: 107985249

RefSeq ID: XR_001738390

Characteristics

Function

  • BMNCR regulates the osteogenic niche of BMSCs by maintaining extracellular matrix protein fibromodulin (FMOD) and activation of the BMP2 pathway. BMNCR affected local 3D chromatin structure and transcription of Fmod[1].
BMNCR regulated Fmod transcription and local 3D chromatin structure[1].
  • BMNCR would serve as a scaffold to facilitate the interaction of TAZ and ABL, and thus facilitate the assembly of the TAZ and RUNX2/PPARG transcriptional complex, promoting osteogenesis and inhibiting adipogenesis[1].

Regulation

In human BMSCs, buthionine-sulfoximine (BSO) downregulates BMNCR expression in a dosage-dependent manner, indicating that elevated oxidative stress at least partially contributes to the reduced BMNCR expression during aging[1].

Diseases

Expression

A high level of BMNCR was detected in the femur and white adipocyte tissue (WAT) in mice. Furthermore, Bone marrow mesenchymal stem cells (BMSCs) and osteoblasts show a higher level of BMNCR expression relative to monocytes and preosteoclasts.[1].

Evolution

Sequence

>XR_001738390.2 PREDICTED: Homo sapiens bone marrow associated non-coding RNA (BMNCR), ncRNA

000001 TTTTCCTTGA TTCCCAGAGT TTCCCTTGTT CTAAATGTAC TGCATGAGCT TCTGAATGTA CTTGGAGATT TACCAGTACC 000080
000081 TCTCCTTGCC AGTTGTAGCT CCTCACCCCA GCCTGTCATC TGTCTGCCCC ACCCTCCTCA ACCTCTGGAC TATAAGAACT 000160
000161 CTGAGCCTTG ACTTAGTTGT CTCTGTATTC TTAGCTTGCG GCAGTGTCTG ACACATAGTA GATGCTGAAT AAATGTCTGC 000240
000241 TGGGAGAATG CATGAATGAA TGAATGCATG GAGGAAGAGG AAGGAGAGGA AGAGAGAGAA GAAGATAGTG GGAAGGAAGA 000320
000321 GAGGAAGAGG AAATAAAAAA CAGGAAAAGG AGATGGAAGA AGAAGGAGAG TGCAGTATAG GGTCGGAAAG AAAAAAGGCA 000400
000401 TCCCTTGATT TGATCTTATC CCCTTTGTCT TCCTGGGGAC TGGAAGGCCC TTCTCAGTTC CTTTCTTTTC CCTCTCCTCC 000480
000481 CAACAGGATA AGGACTTTGG CCACAGCCCT GCCTATCCCC CAGGTATCCC CATAAAGTCT TTAACCCTTA GATATAGAAC 000560
000561 TGCTCTGTCC CTTTTCTACA AAACAAATGT GTTATTTGGG CAGAAGAGGA AAGGAGAAAA TTTGAAGTGG AAAAATCTTT 000640
000641 GGTTTGGAAA TTCAGCTGAC TGCCCTCATT TGGAATAAAA TGTCCTTCAG TCCCTGGCTG TGTGGCAGGC AGGCCCGGCC 000720
000721 AACAGCAACA CCGGATGCCG GGAGACTGGG AGGAGGCCTG GGGATTTTCA GAGGAGCCGC CAGAGTGGTA TGAACTTGGA 000800
000801 ATCCAGGAAG AGAGTGATGG GGCTCATCTC CAAGGGCTGA ATCCCTATCC TCTTCCTCAT CTCTGTCCAG ACAGTGGTCA 000880
000881 GTTGTCCCGA TGTGTCAGGC AGAGTGCTGT CCTGGGGGCA CAGACAGGAC CAGGAGAAGC AAGTCCTGAG GGAGAACAGG 000960
000961 GGCTGGGTCT GTCTCATGTC CTGAGCACCA ACCTCAGCAT CTGACACATG GAAGGTACCC AAGAAACATC AGCTGGGAAA 001040
001041 AAAAAAGTAA CCCTTGTCCC GAGGGGTTGA CAGGAGACCC AGACTTTGCA CTCAGGAGAG AGGGAGGTTG GAAGCGCCAC 001120
001121 TGAGAGGAGT CAGAGGAAAG TGTAAGGAGA CTTGTAAAAA AAGGAGGTGG TCATGAGGAT GAAAGTCATA TGTGAAGGAT 001200
001201 GATGGAACAG AGGGACTAAA GGAGCCTGCC CTGGACACCC TGATTTCCTG CTATGGGGAG TGAAAAAGAA GCCATAGTCC 001280
001281 CATGGATTCT GTTACCAGCC ACTGAGTGCA ATCCTACCTG ATCCCATGGT CCTCACCAAG GCTGTGTCTG CTTAGGAAAT 001360
001361 GGAGAATGGT CCCCAAACCA CAGCAGCAAA AATGAGTGGA AGGGTTGAGC ATTATTTCCA GCCTTGGTTG CTCTGGTGAT 001440
001441 TGGTGCCTGG GAGGGGCAGG ACCTCCATCC AACAGACTGT ACCAGCAGAG TCGTAAGAGG TAGGACTTTG GAGATTCAGC 001520
001521 CGTATGTTCT ATGGGTGGAC TGAAGGCTGA AGGAGGAAGA GGTAGAAGTG CATTGCTACC GACCTACTCC ATCCCACGTG 001600
001601 CAGACTCCCT CGACCCCCAA CCCCAGGCTG TCACCTGCTC CTATATTCAT TTTCTCTGAG GTTGGAGGAA AGAGAAAGGA 001680
001681 GACAGCAATG GCCAGACTTC CCTGGGGTTC CCAAACTGGT TAGTGTGCTC TGCTCAAGTG CTGGCTCCCC GCCCCTCTCT 001760
001761 ATGCACACAC TCAGCCCATG TTCACTGATT CCCATCCTAC CCTCCAGTCA TTTGCCTAAC TGACTTTTTT TTTTCCAGGA 001840
001841 AACCTCAGAG ATGCATTGGA CTTGGTCAGC AGACTTGAGT TCTATGCCCA TGCCAGTCAC TGACTGGCCA TGACCTGAGT 001920
001921 TGGACAAATC ATGCCCACTC TAGACTTAAG TTGTTCCTTA TATGGAAAAG GAAAGGAGTG CTTTGTCAGT GGTTCCCAGA 002000
002001 TACCAATTTA TAAAGATTTC ACTAGTCTGT GGCAAAATAA TATAACAATG GCTATGAATT ACTGGGTATT TCCTTTGTGT 002080
002081 GAAGTGGTTT TCATATATTA ACTCATTTAA TCTCATAACC ACCTGGAAAA GTATGTATTC TTATTAACAC CTTCACATGA 002160
002161 TAGATGATAA AACCAAGGCT CAGAGAGGTT AAGTAACTTA CCTGAAGGTC TTCATATGGT AAGTGGTAGA GCCTGGATTT 002240
002241 GAACTCAGGT ATCCTGGTCC CAGAGTCCAC GTACTAAATC ACTACATTAC AGCTACCCAT GTGATAAGGA AAAAGTAAGG 002320

Labs working on this lncRNA

  • Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
  • Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Hunan, China.

References

  1. 1.0 1.1 1.2 1.3 1.4 Chang-Jun Li, Ye Xiao, Mi Yang, Tian Su, Xi Sun, Qi Guo, Yan Huang, and Xiang-Hang Luo. Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging. J Clin Invest. 2018 Dec 3;128(12):5251-5266.