BCL6-AS1

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BCL6 translocations occur at distinct sequence motifs within intron 1 of the BCL6 gene that are recognized and deaminated by activation-induced cytidine deaminase (AID).

Annotated Information

Name

Approved symbol:BCL6-AS1

Approved name:BCL6 antisense RNA 1

HGNC ID:HGNC:51843

Previous name:BCL6 antisense 1

Alias symbol:lnc-RP11-211G3.3.1-1

Expression

Expression of BCL6-AS1 was detected in the germinal cell B-cell type of DLBCL and at a lower level in the activated B-cell type of diffuse large B-cell lymphoma (DLBCL)[1]

Diseases

diffuse large B-cell lymphoma[1]

Labs working on this lncRNA

  • University of Southern California Norris Comprehensive Cancer Center, Departments of Pathology, Biochemistry & Molecular Biology, Molecular Microbiology & Immunology, and Biological Sciences (Section of Molecular and Computational Biology), University of Southern California Keck School of Medicine, Los Angeles, CA.

References

  1. 1.0 1.1 Lu Z, Pannunzio NR, Greisman HA, Casero D, Parekh C, Lieber MR. Convergent BCL6 and lncRNA promoters demarcate the major breakpoint region for BCL6 translocations. Blood. 2015 Oct 1;126(14):1730-1. doi:10.1182/blood-2015-07-657999. Epub 2015 Aug 14.