BANCR, BRAF activated non-coding RNA,serves as an important regulator in tumorigenesis.
BANCR: BRAF-activated non-protein coding RNA (HGNC nomenclature) LINC00586 
BANCR is a four-exon transcript of 693 bp that is found in a 60 kb gene desert region on chromosome 9. The genes proximal to BANCR are not altered by changes in BANCR expression, indicating that this lncRNA is not a cis regulator of neighbouring genes .
BANCR locus is enriched for chromatin marks associated with active transcription, and interestingly, the BANCR promoter was shown to be enriched for STAT1 transcription factor binding in HeLa-s3 cells (ENCODE ChIP-seq data) .
BANCR is overexpressed in melanoma cells and crucial for melanoma cell migration. Specifically, BANCR expression is significantly lower at the later stages of tumor development, and in tumors that had undergone extensive metastasis.
BANCR is upregulated in Eosinophilic esophagitis (EoE) and induces in interleukin-13 (IL-13)-treated primary esophageal epithelial cells 。
BANCR is downregulated in colorectal cancer tissues .
|Experiment||Forward primer||Reverse primer|
|Quantitative PCR||5'-ACAGGACTCCATGGCAAACG- 3'||5'-ATGAAGAAAGCCTGGTGCAGT- 3'|
|Quantitative PCR||5'-AGACCCCTGACCCTAAGGAA- 3'||5'-TGCTCTTTGCAGAGGTGAGA- 3'|
|qRT-PCR||5'-ACAGGACTCCATGGCAAACG- 3'||5'-ATGAAGAAAGCCTGGTGCAGT- 3'|
Histone acetylation is a key factor in controlling lncRNA BANCR expression .
BANCR inhibits migration and invasion of NSCLC cells and induces apoptosis, which possibly also affectes EMT .
Downregulation of BANCR may be a negative prognostic factor for NSCLC patients, and indicative of poor survival rates and a higher risk for cancer metastasis .
BANCR is a novel BRAFV600E-induced lncRNA that regulates melanoma cell migration in vitro in part by regulating expression of CXCL11 . The genes proximal to BANCR are not altered by changes in BANCR expression, indicating that this lncRNA is not a cis regulator of neighbouring genes .
BANCR promotes proliferation in malignant melanoma by regulating MAPK pathway activation and this is is not only ERK1/2-dependent but also JNK-dependent.
BANCR regulates cell proliferation by targeting p21, and its effects were likely posttranscriptional .
- Bladder cancer 
- Colorectal cancer 
- Eosinophilic esophagitis 
- Esophageal squamous cell cancer 
- Gastric cancer 
- Hepatocellular carcinoma 
- Lung cancer 
- Melanoma 
- Osteosarcoma 
- Papillary thyroid cancer 
- Retinoblastoma 
>gi|392973718|ref|NR_047671.2| Homo sapiens BRAF-activated non-protein coding RNA (BANCR), long non-coding RNA
Labs working on this lncRNA
- Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, People's Republic of China. 
- Veterans Affairs Palo Alto Healthcare System, Palo Alto, California 94304, USA; The Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
- Department of Orthopedics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
- Department of Gastroenterology, Qi-Lu Hospital, Shandong University, Jinan, 250012, Shan Dong Province, People's Republic of China.
- Department of Dermatology, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China.
- Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
- Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China; Taixing People's Hospital, Taixing, Jiangsu, PR China.
- Sun M, Liu XH, Wang KM, Nie FQ, Kong R, Yang JS, et al. Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition[J]. Molecular cancer. 2014,13:68.
- Flockhart RJ, Webster DE, Qu K, Mascarenhas N, Kovalski J, Kretz M, et al. BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration[J]. Genome research. 2012,22(6):1006-14.
- Sherrill JD, Kiran KC, Blanchard C, Stucke EM, Kemme KA, Collins MH, et al. Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing[J]. Genes and immunity. 2014,15(6):361-9.
- Shi Y, Liu Y, Wang J, Jie D, Yun T, Li W, et al. Downregulated Long Noncoding RNA BANCR Promotes the Proliferation of Colorectal Cancer Cells via Downregualtion of p21 Expression[J]. PloS one. 2015,10(4):e0122679.
- Li R, Zhang L, Jia L, Duan Y, Li Y, Bao L, et al. Long non-coding RNA BANCR promotes proliferation in malignant melanoma by regulating MAPK pathway activation[J]. PloS one. 2014,9(6):e100893.
- Chen, J.X., Chen, M., Zheng, Y.D., Wang, S.Y. and Shen, Z.P. (2015) Up-regulation of BRAF activated non-coding RNA is associated with radiation therapy for lung cancer. Biomed Pharmacother, 71, 79-83.
- Jiang, W., Zhang, D., Xu, B., Wu, Z., Liu, S., Zhang, L., Tian, Y., Han, X. and Tian, D. (2015) Long non-coding RNA BANCR promotes proliferation and migration of lung carcinoma via MAPK pathways. Biomed Pharmacother, 69, 90-95.
- Guo, Q., Zhao, Y., Chen, J., Hu, J., Wang, S., Zhang, D. and Sun, Y. (2014) BRAF-activated long non-coding RNA contributes to colorectal cancer migration by inducing epithelial-mesenchymal transition. Oncol Lett, 8, 869-875.
- Liao, T., Qu, N., Shi, R.L., Guo, K., Ma, B., Cao, Y.M., Xiang, J., Lu, Z.W., Zhu, Y.X., Li, D.S. et al. (2016) BRAF-activated LncRNA functions as a tumor suppressor in papillary thyroid cancer. Oncotarget, 8, 238-247.
- Li, L., Zhang, L., Zhang, Y. and Zhou, F. (2015) Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer. Biomed Pharmacother, 72, 109-112.
- Liu, Z., Yang, T., Xu, Z. and Cao, X. (2016) Upregulation of the long non-coding RNA BANCR correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma. Biomed Pharmacother, 82, 406-412.
- Su, S., Gao, J., Wang, T., Wang, J., Li, H. and Wang, Z. (2015) Long non-coding RNA BANCR regulates growth and metastasis and is associated with poor prognosis in retinoblastoma. Tumour Biol, 36, 7205-7211.
- He, A., Liu, Y., Chen, Z., Li, J., Chen, M., Liu, L., Liao, X., Lv, Z., Zhan, Y., Zhuang, C. et al. (2016) Over-expression of long noncoding RNA BANCR inhibits malignant phenotypes of human bladder cancer. J Exp Clin Cancer Res, 35, 125.
- Li, A.X., Xin, W.Q. and Ma, C.G. (2015) Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR. Biochem Biophys Res Commun, 465, 594-600.
- Zhang, Z.X., Liu, Z.Q., Jiang, B., Lu, X.Y., Ning, X.F., Yuan, C.T. and Wang, A.L. (2015) BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-kappaB1. Biochem Biophys Res Commun, 465, 225-231.
- Zhou T, Gao Y. Increased expression of LncRNA BANCR and its prognostic significance in human hepatocellular carcinoma[J]. World journal of surgical oncology. 2016,14(1):8.
- Hombach, S. and Kretz, M. (2013) The non-coding skin: exploring the roles of long non-coding RNAs in epidermal homeostasis and disease. Bioessays, 35, 1093-1100.
- Peng ZQ, Lu RB, Xiao DM, Xiao ZM. Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma[J]. Genetics and molecular research : GMR. 2016,15(1).
- He, N. and Zhang, Z. (2015) Baicalein suppresses the viability of MG-63 osteosarcoma cells through inhibiting c-MYC expression via Wnt signaling pathway. Mol Cell Biochem, 405, 187-196.
- Wang, Y., Guo, Q., Zhao, Y., Chen, J., Wang, S., Hu, J. and Sun, Y. (2014) BRAF-activated long non-coding RNA contributes to cell proliferation and activates autophagy in papillary thyroid carcinoma. Oncol Lett, 8, 1947-1952.
- Zheng, H., Wang, M., Jiang, L., Chu, H., Hu, J., Ning, J., Li, B., Wang, D. and Xu, J. (2015) BRAF-Activated Long Noncoding RNA Modulates Papillary Thyroid Carcinoma Cell Proliferation through Regulating Thyroid Stimulating Hormone Receptor. Cancer Res Treat, 48, 698-707.
- Li, F., Wen, X., Zhang, H. and Fan, X. (2016) Novel Insights into the Role of Long Noncoding RNA in Ocular Diseases. Int J Mol Sci, 17, 478.