Same as lnc-RASA1-3:25
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Intergenic, 2 exon transcript in mouse, with HeK4me3 chromtain mark at 5' (Chodroff (2010)). Human ortholog is linc-POLR3G-8 (Cabili (2011)). Human ortholog has a number of splice isoforms with 3 or more exons.
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Expressed in specific regions of embryonic and post-natal mouse brain (see Chodroff for details) including the rostal migratory stream at P3 with a °∞potential association with inhibitory GABAergic neurons°± (Chodroff (2010)). Expressed in opossum and chicken embryonic brains showing spatio-temporal conservation of expression (Chodroff (2010)).
Highly conserved for a lincRNA 36.7% mouse transcript overlaps phastCons elements (Chodroff (2010)). Conserved in mammals and back to frog, although mouse exon 2 is not conserved in all orthologs (Chodroff (2010)). Opossum ortholog [GenBank:GU951678]. Frog and chicken ([GenBank: CX847574.1 and CR35248.1] respectively (Chodroff (2010)).
Mouse transcript contains Evofold-predicted RNA secondary structure (Chodroff (2010)). LncRNA transcripts in human from bidirectional promoter with TMEM161B (over 50kb upstream from linc-POLR3G-8 start site) can also share exons 2 and/or 3. See BC047059.
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Allelic Information and Variation
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Labs working on this lncRNA
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