Approved Symbol:ABHD11-AS1:ABHD11 antisense RNA 1
Synonyms:NCRNA00035, WBSCR26, LINC00035
LncBook ID: HSALNT0288881
ABHD11-AS1 RNA is an approximately 473-base-long transcript processed from 4 exonsin human. 
ABHD11-AS1 and its mouse homolog Abhd1os contain 2 small potential ORFs (ORF1, 105 nucleotides and ORF2, 138 nucleotides in mouse), which are conserved across mammals. 
Abhd11os has a neuroprotective effect against mHtt. 
Abhd11os levels are markedly reduced in different mouse models of Huntington disease (HD) 
Abhd11os overexpression produces neuroprotection against an N-terminal fragment of mutant huntingtin, whereas Abhd11os knockdown is protoxic.
Compared with adjacent non-tumor tissues, the expression level of ABHD11-AS1 in gastric cancer tissues was significantly increased. 
|Primer||Forward primer||Reverse primer|
|RT-PCR||Abhd11os-U GGATTGCCTCGGACCTG||Abhd11os-L GCACCCGCTCTCGAAC |
|Knockdown||Abhd11os-directedsmall hairpin RNA (shRNA)||5'GGGATGAAGCCATTGCTAA 3' |
|Luciferase-targeted shRNA||5'CGTACGCGGAATACTTCGA 3' |
ABHD11-AS1 might be a potential biomarker for diagnosis of gastric cancer. 
Labs working on this lncRNA
- CEA, DSV, I²BM, Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France.
- Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, 818 Fenghua Road, Ningbo, 315211, China..
- Francelle L, Galvan L, Gaillard MC, Petit F, Bernay B, Guillermier M, et al. Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo[J]. Neurobiology of aging. 2015,36(3):1601 e7-16.
- Lin X, Yang M, Xia T, Guo J. Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance[J]. Medical oncology. 2014,31(7):42.