ABALON, which is transcribed from the opposite genomic strand of BCL-X and lowly expressed in many tumors, functions to induce BCL-XS isoform and cause apoptosis, exhibiting tumor suppressor activity.
ABALON: apoptotic BCL2L1-antisense long non-coding RNA (HGNC nomenclature)
INXS: intronic BCL-XS-inducing lncRNA 
INXS is an unspliced 1903 nt-long RNA, transcribed by RNA polymerase Ⅱ, 5’-capped. The full length transcript spanned beyond exons 1 and 2, overlapping intron 1 and some of the genomic regions upstream of BCL-X. The half-life of INXS was determined to be ∼3 h, indicating it is stable. 
It belongs to the category of "Antisense" in lncRNA classification.
INXS is a nuclear-enriched transcript .
INXS functions as a critical mediator of BCL-XS splice regulation. Overexpression of INXS will induce BCL-XS isoform accumulation and lead to apoptosis in vitro by activating caspases 3, 7 and 9. INXS may interact with Sam68 splicing-modulator complex to regulate the alternative splicing of BCL-X pre-mRNA, but overexpression or knockdown of INXS does not affect the splicing of other Sam68 target mRNAs .
INXS lncRNA induces tumor regression in vivo when it is overexpressed .
INXS expression is driven by a directional promoter, which contain a GC box and TATA box upstream of the INXS transcription start site. When treated with apoptosis-inducing agents, with increased BCL-XS mRNA, the expression of INXS will also increase. 
- tumor suppressor 
INXS expression level in tumor cell lines from kidney, liver, breast and prostate is 5- to 9-fold lower compared with non-tumor cell lines derived from the same tissues. In patients with renal cell carcinoma, INXS levels are 2- to 60-fold lower in the tumor tissue compared with the matched non-tumor.
|Primer||Forward primer||Reverse primer|
>gi|558605735|gb|KC505631.1| Homo sapiens INXS lncRNA, complete sequence
Labs working on this lncRNA
- Departamento de Bioqu´ımica, Instituto de Qu´ımica, Universidade de S˜ao Paulo, 05508-900 S˜ao Paulo, SP, Brasil .
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 DeOcesano-Pereira, C., Amaral, M.S., Parreira, K.S., Ayupe, A.C., Jacysyn, J.F., Amarante-Mendes, G.P., Reis, E.M. and Verjovski-Almeida, S. (2014) Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis. Nucleic Acids Res, 42, 8343-8355.